MYP_116288
Cyclotide mech-2
Anticancer
Anticancer
▸
Cytotoxic anticancer activity
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Cytotoxic
Antimicrobial
Toxicity / Safety
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Blood cell toxicity
▸
Hemolysis
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Hemolytic
Toxicity / Safety
▸
Cytotoxicity
▸
Cytotoxic
Venom / Toxin
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General toxin
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Cytotoxic
Standard
29 amino acids
C132H209N35O42S6
Standard
GLPTCGETCTLGKCNTPKCTCNWPICYKD
3150.67 Da
7.77
0.70
0.40
0.0243
-0.36
0.27
0.01
26.75
40.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
1227.76
-14.84
47.0
49.0
96.0
215.0
6.0
30.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0338135
VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Anticancer
Cytotoxic
Human skin melanoma MM96L
21.94±1.90 μM
IC50
RECORD: Rec_0403625
VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Anticancer
MM96L
21.94±1.9 μM
CC50
RECORD: Rec_0405380
VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Anticancer
Hemolytic
Human erythrocytes: >64μM
50 %
Hemolysis
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