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MYP_116288
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Basic Information
Cyclotide mech-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C132H209N35O42S6
Standard
Sequence
GLPTCGETCTLGKCNTPKCTCNWPICYKD
Physicochemical Analysis
3150.67 Da
7.77
0.70
0.40
0.0243
-0.36
0.27
0.01
26.75
40.34
0.0690
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1227.76
-14.84
47.0
49.0
96.0
215.0
6.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0154480 VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
HeLa
36.92±3.25 μM
CC50
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0201068 VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Anticancer Cytotoxic
Human cervical carcinoma HeLa
36.92±3.25 μM
IC50
PaperPubMed PMID 26322745 | Ravipati et al. 2015 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
RECORD: Rec_0271311 VERIFIED: NO
Provenance & Taxonomy
Melicytus chathamicus [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCyclotide mech-2 Evidence URLhttps://www.uniprot.org/uniprotkb/C0HK36/entry
RECORD: Rec_0285751 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
RECORD: Rec_0329660 VERIFIED: YES
Provenance & Taxonomy
Melicytus chathamicus [Animal]
Cyclotide
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 26322745 PMID26322745 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26322745/
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