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MYP_116277
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Basic Information
galacardin B
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Antimalarial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide
Delivery / Targeting ▸ Drug delivery vehicle
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
13 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XXXXXXXXXXXXX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0261848 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
5(6)-Carboxyfluorescein
Amidation
Z=NLys from N-tert-butoxycarbonyl-1,4-butanediamine; X=NLeu from isobutylamine
Bio-Activity Profile
Antimicrobial Anticancer
Not available
PMID22828784 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22828784/
RECORD: Rec_0292058 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Cyclic peptide
Structure & Mods
cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Methylation
None
R1=CH3CHCH3CH2CH3, R2=R3=CH2C6H6, R4=NH(CH3),hydroxyproline
Bio-Activity Profile
Antimicrobial Antiparasitic Antimalarial
Plasmodium falciparum K1
4.2 μM
IC50; [3H] Hypoxanthine incorporation assay
PMID21450320 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21450320/
RECORD: Rec_0388619 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
5(6)-Carboxyfluorescein
Amidation
Z=NLys from N-tert-butoxycarbonyl-1,4-butanediamine; X=NLeu from isobutylamine
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID22828784 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22828784/
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