Peptide Database

Peptide NameConorfamide As1a

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC76H118N20O13

DescriptionStandard

        RIKKPIFAFPRF
    

Molecular Weight1519.88 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)3.76

Net Charge (pH 7.4) 3.55

Charge Density (pH 7.0) 0.3132

GRAVY Index-0.07

Hydrophobic Moment 0.67

Boman Index-0.07

Instability Index5.58

Aliphatic Index 73.33

Aromaticity 0.2500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 541.68

LogP -0.63

H-bond Donors 19.0

H-bond Acceptors 17.0

Rotatable Bonds 47.0

Heavy Atoms 109.0

Ring Count 5.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0196826 VERIFIED: YES

Provenance & Taxonomy

OrganismConus austini [Animal]

FamilyConorfamide As1a

Tax ID289020

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Acid-sensing ion channel modulator Nicotinic acetylcholine receptor inhibitor Ion channel modulator Neuropeptide

TargetASIC1a; ASIC3; alpha7 nicotinic acetylcholine receptor; muscle-type nicotinic acetylcholine receptor

Activity- -

MethodFLIPR assay; electrophysiology / ion-channel modulation assay

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min