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MYP_116210
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Basic Information
N46eg(SARS-CoV (902-947)[K2N,I4S,N9Q,A11E,Q16N,S18V,S23N,A25S,V32D,A37N,A39S,V44Q,Q46E])
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
46 amino acids
C216H356N66O83
Standard
Sequence
QNQSANQFQKEISQINEVLTTTNTSLGKLQDDVNQNNQSLNTLQKE
Physicochemical Analysis
5205.53 Da
4.69
-2.23
-2.44
-0.0484
-1.19
0.63
-0.24
36.78
74.13
0.0217
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2551.98
-38.06
81.0
81.0
186.0
365.0
1.0
62.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0309235 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0312090 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Fusion inhibitor
694009
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Severe acute respiratory syndrome coronavirus
5.07 μM
IC50
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0345497 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0350086 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-CoV
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0424066 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Vero E6 cells
0 % Cytotoxicity
Cytotoxicity
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
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