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MYP_116210
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Basic Information
N46eg(SARS-CoV (902-947)[K2N,I4S,N9Q,A11E,Q16N,S18V,S23N,A25S,V32D,A37N,A39S,V44Q,Q46E])
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
46 amino acids
C216H356N66O83
Standard
Sequence
QNQSANQFQKEISQINEVLTTTNTSLGKLQDDVNQNNQSLNTLQKE
Physicochemical Analysis
5205.53 Da
4.69
-2.23
-2.44
-0.0484
-1.19
0.63
-0.24
36.78
74.13
0.0217
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2551.98
-38.06
81.0
81.0
186.0
365.0
1.0
62.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0100502 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
SARS-CoV:inhibition of cell fusion in Hela cells
5.07±0.17 μM
IC50
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0144628 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Human cervical carcinoma HeLa
0-10 % Cytotoxicity
Cytotoxicity
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0153728 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
No discernable cytotoxicity on HeLa or VeroE6 cells at the concentrations of 25 μM
PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0285927 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-SARS-CoV Fusion inhibition
SARS-CoV | of cell; Hela cells
5.07±0.17 μM
IC50
Mammalian: 0.8 h; Yeast: 10 min; E. coli: >10 h
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK. | Antiviral Res. 2009 Jan;81(1):82-7. | DOI:10.1016/j.antiviral.2008.10.001 | PMID:18983873 PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
RECORD: Rec_0302087 VERIFIED: YES
Provenance & Taxonomy
Severe acute respiratory syndrome-related coronavirus [Virus]
Virus-derived peptide
694009;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
SARS coronavirus (Virus entry); HeLa
5.07 μM
beta-galactosidase activity
PaperIdentification of a minimal peptide derived from heptad repeat (HR) 2 of spike protein of SARS-CoV and combination of HR1-derived peptides as fusion inhibitors. | Liu IJ, Kao CL, Hsieh SC, Wey MT, Kan LS, Wang WK. | Antiviral Res. 2009 | PMID:18983873 PMID18983873 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18983873/
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