Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2321H3730N590O666S22

DescriptionStandard

        MSPCCLLALLAVISLTLAASPGVKVKLTDKGIEYGKQIGMASLQQKLKTMKVPDLSGTEKVPPIGKVKYSLTGMTIVNLGLPKSALVLMPGTGVRLAITNAFINLHGNWRVRYFRFIQDRGSFDLAVNGLTITADIAIKSDETGRPTVSTVNCVANVGSASIKFHGGASWLYNLFKSYIDKALRSALQKQICPLVADVITDMNPHLKTFNVLAKVDQYAEIEYSMVTSPTISKSSIEFSLKGEFYNIGKHQEPPFSPTPFSLPPQDNNMLYIGVSSFTPNSAGFVYNNAGALSLYVTDDMIPPSSPIRLNTGTFGVFIPEIAKRFPGMMMKLLVKTVKEPTISLEPNNVTVQASGTVTAYAIQPNTTLSPLFVLNMEGSVSAQMNVTGVKLAGAITLNKIEMTLGTSYVGQFQVQSLDNIFLMVLKVVVIPKVNARLEKGFPLPTIGKMNLINTQLQVLKDYMLIGTDVQFTG
    

Molecular Weight51261.43 Da

Isoelectric Point (pI)9.34

Net Charge (pH 7.0)11.82

Net Charge (pH 7.4) 11.24

Charge Density (pH 7.0) 0.0250

GRAVY Index0.19

Hydrophobic Moment 0.70

Boman Index0.17

Instability Index32.09

Aliphatic Index 100.53

Aromaticity 0.0782

Extinction Coeff. Reduced 31860.00

Extinction Coeff. Oxidized 32110.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0147788 VERIFIED: NO

Provenance & Taxonomy

OrganismOncorhynchus mykiss [Animal]

FamilyBPI/LBP

Tax ID8022

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence