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MYP_116094
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Basic Information
Cliotides T20, CT20
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C129H218N40O41S6
Standard
Sequence
GSAIRCGESCLLGKCYTPGCTCDRPICKKN
Physicochemical Analysis
3177.74 Da
8.66
2.70
2.40
0.0900
-0.23
0.48
-0.09
46.39
55.33
0.0333
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1310.34
-17.40
52.0
50.0
104.0
216.0
3.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0025936 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
A549
>10 μM
IC50
PMID23419988 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23419988/
RECORD: Rec_0095619 VERIFIED: NO
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperCliotide T20 (Cyclotide cT20) Evidence URLhttps://www.uniprot.org/uniprotkb/C0HJS7/entry
RECORD: Rec_0098181 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
6-20; 10-22; 15-27
Bio-Activity Profile
Antimicrobial Antibacterial Immunomodulator Anti-Gram-negative
Escherichia coli
0.5 μM
MIC
RECORD: Rec_0134572 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
0.5 μM
MIC
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Nguyen et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
RECORD: Rec_0145431 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Animal]
Cyclotide
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibiotic Defense peptide Anti-Gram-negative Anti-Gram-positive Cytotoxic Non-hemolytic
Escherichia coli (Gram-negative)
PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
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