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MYP_116086
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Basic Information
Peptide 15(lactoferrin 422-425)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-H1N1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Standard
4 amino acids
C16H28N4O8S
Standard
Sequence
SLDC
Physicochemical Analysis
436.48 Da
4.05
-1.55
-1.77
-0.3871
0.50
0.32
0.07
7.50
97.50
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
208.15
-2.70
8.0
8.0
13.0
29.0
0.0
3.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0084084 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
A/Parma/24/09 H1N1:inhibition of virus replication in MDCK cells
0.000005±0 μM
EC50
PMID28878220;34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0103218 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
A/Parma0/5/06 H3N2:inhibition of virus replication in MDCK cells
0.000004±0 μM
EC50
PMID28878220;34681184 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0113162 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Ac
Amidation
Bio-Activity Profile
Antiviral
A/Roma-ISS/02/08 H1N1
0.5±0.001
EC50
PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0116145 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-H3N2 Replication inhibition
A/Parma0/5/06 H3N2 | MDCK cells
0.0000043±0.00000003 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
RECORD: Rec_0197720 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Lactoferrin-derived peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation
Amidation
Acylation
Bio-Activity Profile
Antiviral Anti-H1N1 Replication inhibition
A/Parma/24/09 H1N1 | MDCK cells
0.0000046±0.00000005 μM
EC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperLactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors. | Scala MC, Sala M, Pietrantoni A, Spensiero A, Di Micco S, Agamennone M, Bertamino A, Novellino E, Bifulco G, Gomez-Monterrey IM, Superti F, Campiglia P. | Sci Rep. 2017 Sep 6;7(1):10593. | DOI:10.1038/s41598-017-10492-x | PMID:28878220 PMID28878220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28878220/
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