Peptide Database

Peptide NameSLAY-screened peptide P1318

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length10 amino acids

Chemical FormulaC58H79N19O13S

DescriptionStandard

        HMPHTTWHVH
    

Molecular Weight1282.43 Da

Isoelectric Point (pI)7.10

Net Charge (pH 7.0)0.11

Net Charge (pH 7.4) -0.30

Charge Density (pH 7.0) 0.0109

GRAVY Index-1.06

Hydrophobic Moment 0.17

Boman Index0.10

Instability Index54.05

Aliphatic Index 29.00

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 487.40

LogP -2.97

H-bond Donors 17.0

H-bond Acceptors 18.0

Rotatable Bonds 34.0

Heavy Atoms 91.0

Ring Count 7.0

Amide Bonds 9.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0176348 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/