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MYP_116031
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
22 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
GFXGXKKXGXFXGXGKKXKKKK
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0359753 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X=A6c (1-aminocyclohexane carboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
IGROV-1
>7.5 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0368970 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
X=A6c (1-aminocyclohexane carboxylic acid)
Bio-Activity Profile
Antimicrobial Anticancer
DLD-1
>7.5 μM
IC50
PaperAntibacterial and anticancer activity of a series of novel peptides incorporating cyclic tetra-substituted C(alpha) amino acids. Bioorg Med Chem. 2016 Sep 15;24(18):4056-4065. doi: 10.1016/j.bmc.2016.06.048. PMID: 27387357. PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0380690 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 3,5,8,10,12,14,18
Bio-Activity Profile
Antimicrobial Antibacterial
Burkholderia pseudomallei NCTC 8016
39 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0381370 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic designed peptide
32630
Structure & Mods
linear peptide [Linear]
all-D amino-acid peptide [D]
Acetylation
Amidation
A6c = 1-aminocyclohexane carboxylic acid,
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis XDR
4.92 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
RECORD: Rec_0408531 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
unspecified non-canonical residue at 3,5,8,10,12,14,18
Bio-Activity Profile
Antimicrobial Antibacterial
Yersinia pestis NR641
39 μM
MIC
PMID27387357 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27387357/
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