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MYP_116009
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Basic Information
DN57opt
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
28 amino acids
C176H252N56O36S
Standard
Sequence
RWMVWRHWFHRLRLPYNPGKNKQNQQWP
Physicochemical Analysis
3760.30 Da
12.00
5.93
5.62
0.2118
-1.67
0.54
-0.34
75.19
38.21
0.2143
23490.00
23490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1521.58
-9.11
53.0
45.0
115.0
269.0
15.0
33.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0135662 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
the peptide was found to be mildly toxic to LLC-MK2 cells at 40 μM
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0175184 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0251066 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0299924 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Dengue 2 virus (Virus entry); LLC-MK2
8 μM
Focus reduction assay
PaperStructural optimization and de novo design of dengue virus entry inhibitory peptides. | Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. | PLoS Negl Trop Dis. 2010 | PMID:20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0320887 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Entry inhibition
Dengue 2 virus(DENV-2) | LLC-MK2 cells
8±1 μM
IC50
Mammalian: 1 h; Yeast: 2 min; E. coli: 2 min
PaperStructural optimization and de novo design of dengue virus entry inhibitory peptides. | Costin JM, Jenwitheesuk E, Lok SM, Hunsperger E, Conrads KA, Fontaine KA, Rees CR, Rossmann MG, Isern S, Samudrala R, Michael SF. | PLoS Negl Trop Dis. 2010 Jun 22;4(6):e721. | DOI:10.1371/journal.pntd.0000721 | PMID:20582308 PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
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