Peptide Database

Peptide NameAcetyl-[Ala14, Ala20]PACAP38-propylamide

Function Ontology

Neuroprotective

Standard StatusStandard

Sequence Length38 amino acids

Chemical FormulaC197H316N58O54S

DescriptionStandard

        HSDGIFTDSYSRYAKQMAVAKYLAAVLGKRYKQRVKNK
    

Molecular Weight4393.04 Da

Isoelectric Point (pI)10.17

Net Charge (pH 7.0)6.84

Net Charge (pH 7.4) 6.57

Charge Density (pH 7.0) 0.1800

GRAVY Index-0.74

Hydrophobic Moment 0.60

Boman Index-0.22

Instability Index47.41

Aliphatic Index 66.84

Aromaticity 0.1316

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 5960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1876.23

LogP -18.16

H-bond Donors 68.0

H-bond Acceptors 63.0

Rotatable Bonds 151.0

Heavy Atoms 310.0

Ring Count 6.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0308326 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyPACAP

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Neuroprotective

Activity0.0053±0.0017 μM

MethodIC50

Half-LifeDPP IV, in vitro; >14400 s