Peptide Database

Peptide NameBeta-defensin 50

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length73 amino acids

Chemical FormulaC356H577N95O93S7

DescriptionStandard

        MKTLHLLLLISGLLSVFVKGVGSHPGTVHVRFKCIPKIAAVFGDNCPFYGNVDGLCNDKKSVCCMVPVRLDNI
    

Molecular Weight7900.42 Da

Isoelectric Point (pI)8.97

Net Charge (pH 7.0)3.71

Net Charge (pH 7.4) 3.26

Charge Density (pH 7.0) 0.0508

GRAVY Index0.55

Hydrophobic Moment 0.55

Boman Index0.22

Instability Index21.53

Aliphatic Index 111.92

Aromaticity 0.0685

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1740.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2952.49

LogP -23.65

H-bond Donors 105.0

H-bond Acceptors 107.0

Rotatable Bonds 258.0

Heavy Atoms 551.0

Ring Count 12.0

Amide Bonds 76.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0399815 VERIFIED: NO

Provenance & Taxonomy

OrganismRattus norvegicus [Animal]

FamilyDefensin

Tax ID10116

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Defensin Non-hemolytic Non-ribosomal

MethodQualitative functional evidence

PaperCross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract PMID16033865 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16033865/; https://www.uniprot.org/uniprotkb/Q30KJ2/entry; https://bblserver.org.in/ampdb/