Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 1.1 (ChTX-Lq1) (ChTx-a) (Charybdotoxin) (CTX) (ChTX)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length59 amino acids

Chemical FormulaC287H474N82O82S9

DescriptionStandard

        MKILSVLLLALIICSIVGWSEAQFTNVSCTTSKECWSVCQRLHNTSRGKCMNKKCRCYS
    

Molecular Weight6673.92 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)5.52

Net Charge (pH 7.4) 5.14

Charge Density (pH 7.0) 0.0935

GRAVY Index0.19

Hydrophobic Moment 0.54

Boman Index0.04

Instability Index44.04

Aliphatic Index 89.15

Aromaticity 0.0678

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2680.22

LogP -28.69

H-bond Donors 104.0

H-bond Acceptors 98.0

Rotatable Bonds 226.0

Heavy Atoms 460.0

Ring Count 7.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0015325 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetCandida albicans

RECORD: Rec_0019881 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetBacillus subtilis (Gram-positive)

RECORD: Rec_0194928 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0314869 VERIFIED: YES

Provenance & Taxonomy

OrganismLeiurus hebraeus [Animal]

FamilyShort scorpion toxin; Potassium channel inhibitor; Alpha-KTx 01 subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Toxin Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)