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MYP_115967
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Basic Information
Phylloseptin-2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
19 amino acids
C101H154N26O24
Standard
Sequence
FLSLIPHAINAVSTLVHHF
Physicochemical Analysis
2116.46 Da
7.02
0.02
-0.33
0.0011
1.11
0.50
0.50
2.50
143.68
0.1053
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
768.15
-4.16
26.0
27.0
63.0
151.0
6.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0229614 VERIFIED: YES
Provenance & Taxonomy
Pithecopus hypochondrialis [Animal]
317381
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPhylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus.
RECORD: Rec_0234855 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli
60.4 μM
MIC
PMID15752569;18656510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
RECORD: Rec_0250716 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Phylloseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Klebsiella pneumoniae
60.4 μM
MIC
PMID15752569;18656510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15752569/
RECORD: Rec_0269602 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
15 μM
MIC
PMID23029273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23029273/
RECORD: Rec_0276226 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa hypochondrialis [Animal]
frog skin active peptide (FSAP) family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial frog skin active peptide (FSAP) family Antibacterial Host defense
PaperPDB 2JPY structural record; NMR; chain A; residues 1-19
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