Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length194 amino acids

Chemical FormulaC983H1562N266O259S9

DescriptionStandard

        PKTLPMAREPMLLLAVTDFVASSAAFTYFTAGALRKNISHDMLPQKFPLQLRTKNMEVFSPQLLERYQDQPMELHLWARRQPLLSCHPDALHGTLFSSAEAFVVLPNTTRVPVFLLNIDANVTGKPIITRNRLGGTVRLTGGALPVPQTPLPALCWAQGLPVLQVKRLETLLKFGLWLFGVPRANSECCPHPVP
    

Molecular Weight21539.13 Da

Isoelectric Point (pI)9.64

Net Charge (pH 7.0)7.37

Net Charge (pH 7.4) 6.97

Charge Density (pH 7.0) 0.0380

GRAVY Index0.09

Hydrophobic Moment 0.54

Boman Index0.11

Instability Index56.15

Aliphatic Index 99.54

Aromaticity 0.0773

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 8228.10

LogP -97.11

H-bond Donors 282.0

H-bond Acceptors 280.0

Rotatable Bonds 680.0

Heavy Atoms 1517.0

Ring Count 44.0

Amide Bonds 209.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067787 VERIFIED: NO

Provenance & Taxonomy

OrganismGrallaria varia [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria