Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length176 amino acids

Chemical FormulaC885H1398N238O239S10

DescriptionStandard

        PMTPPMEHEPMLLLAVTEFVANSAAFTYYTAGALHRNISMLPRRFPLQLSTKSMEVFSPQLQERYPDQPMELHLWARQQPLLSCHPDALHGTLFSSAEAFVVLPNATRVPAFLLNIDANVTGKPTITRNRLGGTVRLTGLGLPVLQVKRLETVLKFGLWLFGVPQANSKCCPCPVP
    

Molecular Weight19516.67 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)4.37

Net Charge (pH 7.4) 3.98

Charge Density (pH 7.0) 0.0248

GRAVY Index0.06

Hydrophobic Moment 0.76

Boman Index0.12

Instability Index51.97

Aliphatic Index 93.64

Aromaticity 0.0795

Extinction Coeff. Reduced 15470.00

Extinction Coeff. Oxidized 15720.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7470.09

LogP -77.88

H-bond Donors 256.0

H-bond Acceptors 258.0

Rotatable Bonds 614.0

Heavy Atoms 1372.0

Ring Count 40.0

Amide Bonds 190.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0161775 VERIFIED: NO

Provenance & Taxonomy

OrganismTychaedon coryphoeus (Karoo scrub-robin) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria