Peptide Database

Peptide Namehelodermin

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC176H284N46O50

DescriptionStandard

        HSDAIFTQQYSKLLAKLALQKYLASILGSRTSPPP
    

Molecular Weight3844.42 Da

Isoelectric Point (pI)9.82

Net Charge (pH 7.0)2.84

Net Charge (pH 7.4) 2.58

Charge Density (pH 7.0) 0.0812

GRAVY Index-0.14

Hydrophobic Moment 0.54

Boman Index0.06

Instability Index49.94

Aliphatic Index 100.57

Aromaticity 0.0857

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1543.63

LogP -14.77

H-bond Donors 53.0

H-bond Acceptors 54.0

Rotatable Bonds 124.0

Heavy Atoms 272.0

Ring Count 7.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0169474 VERIFIED: YES

Provenance & Taxonomy

OrganismHeloderma suspectum [Animal]

Familyhelodermin

Tax ID8554

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

-

Half-LifeMammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0215738 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/