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MYP_115904
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Basic Information
Deltorphin I
Antimicrobial
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of ileum cells contraction
Enzyme modulation ▸ Enzyme inhibition ▸ Inhibition of vas deferens cells contraction
Neurological / Signaling ▸ Analgesic/antinociceptive activity
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Standard
7 amino acids
C37H51N7O11
Standard
Sequence
YAFDVVG
Physicochemical Analysis
769.84 Da
4.05
-1.24
-1.44
-0.1771
1.11
0.37
0.54
47.90
97.14
0.2857
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
295.45
-1.06
10.0
10.0
21.0
55.0
2.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0150019 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Opioid
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Opioid Analgesic Neuromodulator
PMID18395423 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18395423/
RECORD: Rec_0181712 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0291931 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa bicolor [Animal]
-deltorphin-1
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Inhibition of ileum cells contraction Inhibition of vas deferens cells contraction Mu-receptor affinity Delta-receptor affinity Antinociceptive
PaperK. Richter et al. / PNAS 87 (1990) 4836-4839. cDNAs encoding [D-Ala2]deltorphin precursors from skin of Phyllomedusa bicolor also contain genetic information for three dermorphin-related opioid peptides Evidence URLhttps://www.uniprot.org/uniprotkb/P21850/entry
RECORD: Rec_0295423 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0347184 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Deltorphin
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
-
Mammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Deltorphin I (Homo sapiens): PMID 18395423 PMID18395423 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18395423/
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