Peptide Database

Peptide NameSLAY-screened peptide P464

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H167N39O26S2

DescriptionStandard

        DFVNRLRRFLCNRMHPNAAH
    

Molecular Weight2467.84 Da

Isoelectric Point (pI)11.52

Net Charge (pH 7.0)2.93

Net Charge (pH 7.4) 2.61

Charge Density (pH 7.0) 0.1463

GRAVY Index-0.73

Hydrophobic Moment 0.77

Boman Index-0.31

Instability Index66.95

Aliphatic Index 63.50

Aromaticity 0.1000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1078.96

LogP -10.84

H-bond Donors 39.0

H-bond Acceptors 33.0

Rotatable Bonds 79.0

Heavy Atoms 173.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0117672 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/