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MYP_115869
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Basic Information
limnonectin-1Fa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
16 amino acids
C89H138N24O18S2
Standard
Sequence
SFPFFPPGICKRLKRC
Physicochemical Analysis
1896.33 Da
10.11
3.44
3.20
0.2149
-0.07
0.61
-0.05
87.66
48.75
0.1875
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
669.52
-3.72
25.0
24.0
57.0
133.0
6.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0209345 VERIFIED: YES
Provenance & Taxonomy
Limnonectes fujianensis [Animal]
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
10-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
160 μM
Hemolysis
PaperPubMed PMID: 21396976 PMID21396976 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21396976/
RECORD: Rec_0244967 VERIFIED: YES
Provenance & Taxonomy
Limnonectes fujianensis [Animal]
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
10-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Hemolytic
PaperPubMed PMID: 21396976 PMID21396976 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21396976/
RECORD: Rec_0252186 VERIFIED: YES
Provenance & Taxonomy
Limnonectes fujianensis [Animal]
Limnonectin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
10-16
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
160.0 μM
MIC
PaperY. Wu et al. / Biochimie 93 (2011) 981-987. Limnonectins: a new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis) Evidence URLhttps://www.uniprot.org/uniprotkb/F4N9N4/entry
RECORD: Rec_0288100 VERIFIED: YES
Provenance & Taxonomy
Limnonectes fujianensis [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0296881 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Horse erythrocytes
160 μM
Hemolysis
Paperhttps://pubmed.ncbi.nlm.nih.gov/21396976/ PMID21396976 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21396976/
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