Peptide Database

Peptide NameSLAY-screened peptide P3619

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC93H144N32O31S

DescriptionStandard

        CHIGEVADGSLFQNNNRNIH
    

Molecular Weight2238.40 Da

Isoelectric Point (pI)5.99

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.0536

GRAVY Index-0.65

Hydrophobic Moment 0.52

Boman Index-0.06

Instability Index74.06

Aliphatic Index 78.00

Aromaticity 0.0500

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1045.76

LogP -13.85

H-bond Donors 35.0

H-bond Acceptors 33.0

Rotatable Bonds 74.0

Heavy Atoms 157.0

Ring Count 3.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0009266 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/