Peptide Database

Peptide NameTP1[-R5,R17G]

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antifungal

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC89H133N27O19S4

DescriptionStandard

        KWCFVCYRGICYRRCG
    

Molecular Weight2013.44 Da

Isoelectric Point (pI)9.25

Net Charge (pH 7.0)3.72

Net Charge (pH 7.4) 3.45

Charge Density (pH 7.0) 0.2323

GRAVY Index-0.01

Hydrophobic Moment 0.42

Boman Index-0.12

Instability Index13.43

Aliphatic Index 42.50

Aromaticity 0.2500

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8730.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 767.79

LogP -4.86

H-bond Donors 34.0

H-bond Acceptors 27.0

Rotatable Bonds 62.0

Heavy Atoms 139.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0402445 VERIFIED: YES

Provenance & Taxonomy

OrganismSynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configstapled cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Disulfide3-16; 7-12

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetAcinetobacter baumannii clinical isolate 100734512 : 2 (XDR;PmxR)

Activity16 μg/mL

MethodMIC

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