Peptide Database

Peptide NameCyclotide vitri A

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length30 amino acids

Chemical FormulaC135H219N37O40S7

DescriptionStandard

        CESCVWIPCITSAIGCSCKSKVCYRNGIPC
    

Molecular Weight3224.86 Da

Isoelectric Point (pI)8.27

Net Charge (pH 7.0)1.69

Net Charge (pH 7.4) 1.38

Charge Density (pH 7.0) 0.0564

GRAVY Index0.54

Hydrophobic Moment 0.35

Boman Index0.16

Instability Index16.17

Aliphatic Index 74.67

Aromaticity 0.0667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1221.14

LogP -13.96

H-bond Donors 50.0

H-bond Acceptors 49.0

Rotatable Bonds 100.0

Heavy Atoms 219.0

Ring Count 5.0

Amide Bonds 30.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0121056 VERIFIED: YES

Provenance & Taxonomy

OrganismViola tricolor [Plant]

FamilyCyclotide

Tax ID214053

Structure & Mods

Confighead-to-tail cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Antimicrobial Cytotoxic

RECORD: Rec_0335930 VERIFIED: YES

Provenance & Taxonomy

OrganismViola tricolor [Plant]

FamilyCyclotide

Structure & Mods

Configcyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Cytotoxic

TargetU-937 GTB

Activity0.6 μM

MethodIC50