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MYP_115355
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Antimicrobial ▸ Antifungal
Standard
24 amino acids
C140H243N45O31
Standard
Sequence
IGKEFKRIVERIKRFLRELVRPLR
Physicochemical Analysis
3052.71 Da
11.72
5.77
5.55
0.2402
-0.51
1.11
-0.39
43.95
121.67
0.0833
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1285.19
-6.68
48.0
37.0
109.0
216.0
3.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011679 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
PaperPatent US 2008/0249022 A1 Evidence URLhttps://patents.google.com/patent/US20080249022A1/en PatentUS 2008/0249022 A1
RECORD: Rec_0056089 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
72% similar to IG-25 (AP02855), a C-terminal fragment of LL-37 studied by NMR (Li et al., 2006). Chemical modification: N-terminal acetylation (XXE);
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli ATCC 8739
2 μM
MIC
PaperDevelopment of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application.
RECORD: Rec_0074350 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
72% similar to IG-25 (AP02855), a C-terminal fragment of LL-37 studied by NMR (Li et al., 2006). Chemical modification: N-terminal acetylation (XXE);
Bio-Activity Profile
Antimicrobial Antifungal
A. niger ATCC 14406
18 μM
MIC
PaperDevelopment of novel LL-37 derived antimicrobial peptides with LPS and LTA neutralizing and antimicrobial activities for therapeutic application.
RECORD: Rec_0183859 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Cathelicidin-derived
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Bio-Activity Profile
Antibacterial
multidrug-resistant bacterial isolates (clinical study context)
PaperThe Antibacterial Effects of Antimicrobial Peptides OP-145 against Clinically Isolated Multi-Resistant Strains PMID28890511 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28890511/
RECORD: Rec_0232178 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperBaAMPs: the database of biofilm-active antimicrobial peptides PMID25760404 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25760404/
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