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MYP_115266
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Basic Information
Brevinin-2-related peptide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
21 amino acids
C107H175N27O28S
Standard
Sequence
GIWDTIKSMGKVFAGKILQNL
Physicochemical Analysis
2319.76 Da
9.70
1.76
1.55
0.0837
0.29
0.61
0.23
2.80
111.43
0.0952
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
903.11
-6.01
31.0
31.0
80.0
163.0
3.0
22.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0350036 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
70 μM
MIC
PMID15556063 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
RECORD: Rec_0360964 VERIFIED: NO
Provenance & Taxonomy
Mink frog [Animal]
Brevinin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0364029 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 66.7%, E 0.0%, T 14.3%, C 19.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0364324 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Antiviral
Human immunodeficiency virus 1 (HIV-1)
1.65 μM
EC50
PaperPurification and characterization of antimicrobial peptides from the skin secretions of the mink frog Rana septentrionalis
RECORD: Rec_0371067 VERIFIED: YES
Provenance & Taxonomy
Rana septentrionalis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Refer PubMed ID - 31549575 (C terminal: NH2): Staphylococcus aureus
16
MIC
PMID15556063;19793185;31549575 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15556063/
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