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MYP_115144
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Basic Information
Linear Cyclotide Panitide L3
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
not Standard
27 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XAFCGETCLLGKCYTPGCSCHTGICLK
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0080657 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
4-18; 8-20; 13-25
Pyroglutamic acid at position 1 (X=Pyr)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic Anti-Gram-positive
Staphylococcus aureus
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J Biol Chem. 2013;288:3370-3380. DOI:10.1074/jbc.M112.415356 PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0171397 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
-
4-18; 8-20; 13-25
Pyroglutamic acid at position 1 (X=Pyr)
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial
HeLa cells
10 μM
IC50
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J Biol Chem. 2013;288:3370-3380. DOI:10.1074/jbc.M112.415356 PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0241038 VERIFIED: NO
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
-
4-18; 8-20; 13-25
Pyroglutamic acid at position 1 (X=Pyr)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J Biol Chem. 2013;288:3370-3380. DOI:10.1074/jbc.M112.415356 PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0257221 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
4-18; 8-20; 13-25
Pyroglutamic acid at position 1 (X=Pyr)
Bio-Activity Profile
Anticancer Cytotoxic Antimicrobial Antibacterial Antifungal
Human cervical carcinoma HeLa
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J Biol Chem. 2013;288:3370-3380. DOI:10.1074/jbc.M112.415356 PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0265282 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cystine-knot peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
4-18; 8-20; 13-25
Pyroglutamic acid at position 1 (X=Pyr)
Bio-Activity Profile
Anti-Gram-negative Antibacterial Antimicrobial Antifungal Anticancer Cytotoxic
Escherichia coli
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants. J Biol Chem. 2013;288:3370-3380. DOI:10.1074/jbc.M112.415356 PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
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