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MYP_115039
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Basic Information
P18
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
13 amino acids
C59H104N14O19S
Standard
Sequence
GTKALTEVIPLTC
Physicochemical Analysis
1345.60 Da
5.99
-0.25
-0.47
-0.0191
0.70
0.44
0.28
15.30
120.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
527.74
-4.77
19.0
20.0
42.0
93.0
1.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0082288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of PHA-P-activated PBMCs infected with HIV-1-LAI
>1 μM
EC50
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0083638 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of polymerase activity of HIV-1 RT(Ki =53± 12 μM)
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0125798 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Replication inhibition
HIV-1
1 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. | Agopian A, Gros E, Aldrian-Herrada G, Bosquet N, Clayette P, Divita G. | J Biol Chem. 2009 Jan 2;284(1):254-264. | DOI:10.1074/jbc.M802199200 | PMID:18952602 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0259308 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperA New Generation of Peptide-based Inhibitors Targeting HIV-1 Reverse Transcriptase Conformational Flexibility PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0265949 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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