‹ ›
MYP_115039
← PREVIOUS NEXT → BACK
Basic Information
P18
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition
Enzyme modulation ▸ Enzyme inhibition ▸ Reverse transcriptase inhibition
Standard
13 amino acids
C59H104N14O19S
Standard
Sequence
GTKALTEVIPLTC
Physicochemical Analysis
1345.60 Da
5.99
-0.25
-0.47
-0.0191
0.70
0.44
0.28
15.30
120.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
527.74
-4.77
19.0
20.0
42.0
93.0
1.0
12.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0082288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Reverse transcriptase inhibition Anti-HIV-1 Replication inhibition Antiviral Antimicrobial
HIV-1 LAI; PHA-P-activated peripheral blood mononuclear cells (PBMCs)
>1 μM
EC50
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. J Biol Chem. 2009;284:254-264. DOI:10.1074/jbc.M802199200 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0083638 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Reverse transcriptase inhibition Anti-HIV-1 Replication inhibition Antiviral Antimicrobial
HIV-1 reverse transcriptase
53±12 μM
Ki
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. J Biol Chem. 2009;284:254-264. DOI:10.1074/jbc.M802199200 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0125798 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Reverse transcriptase inhibition Anti-HIV-1 Replication inhibition Antiviral Antimicrobial
HIV-1
1 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. J Biol Chem. 2009;284:254-264. DOI:10.1074/jbc.M802199200 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0259308 VERIFIED: NO
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Reverse transcriptase inhibition Anti-HIV-1 Replication inhibition Antiviral Antimicrobial
PaperA new generation of peptide-based inhibitors targeting HIV-1 reverse transcriptase conformational flexibility. J Biol Chem. 2009;284:254-264. DOI:10.1074/jbc.M802199200 PMID18952602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18952602/
RECORD: Rec_0265949 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
-
-
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
1 2 NEXT LAST
Showing 5 records · Page 1 of 2