Peptide Database

Peptide NameHA-pep25

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC97H150N26O26S

DescriptionStandard

        SKVNGQSGRMEFFWTILK
    

Molecular Weight2128.45 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.46

Net Charge (pH 7.4) 1.25

Charge Density (pH 7.0) 0.0812

GRAVY Index-0.38

Hydrophobic Moment 0.30

Boman Index0.00

Instability Index18.42

Aliphatic Index 59.44

Aromaticity 0.1667

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 871.92

LogP -7.49

H-bond Donors 31.0

H-bond Acceptors 29.0

Rotatable Bonds 72.0

Heavy Atoms 150.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0260337 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Term-

C-Term-

Bio-Activity Profile

Function

Antimicrobial Antiviral

RECORD: Rec_0281768 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Term-

C-Term-

Bio-Activity Profile

Function

Entry inhibition Anti-Influenza A virus Antiviral Antimicrobial

TargetInfluenza A virus A/Vietnam/1203/2004; MDCK cells

Activity12±2.1 μM

MethodIC50

RECORD: Rec_0293124 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Term-

C-Term-

Bio-Activity Profile

Function

Entry inhibition Anti-Influenza A virus Antiviral Antimicrobial

TargetInfluenza A virus A/Goose/Qinghai/59/2005; MDCK cells

Activity34.8±1.5 μM

MethodIC50

RECORD: Rec_0363330 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Term-

C-Term-

Bio-Activity Profile

Function

Entry inhibition Anti-Influenza A virus Antiviral Antimicrobial

TargetInfluenza A virus A/Goose/Qinghai/59/2005

Activity34.8±1.5 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperInfluenza Viral Hemagglutinin Peptide Inhibits Influenza Viral Entry by Shielding the Host Receptor | Influenza Viral Hemagglutinin Peptide Inhibits Influenza Viral Entry by Shielding the Host Receptor | ACS Infect Dis. 2016 Mar 11;2(3):187-93 | DOI:10.1021/acsinfecdis.5b00139 | PMID:27623031 PMID27623031 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27623031/

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