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MYP_114927
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Basic Information
Brevinin-2SN4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
30 amino acids
C132H225N37O39S3
Standard
Sequence
GAFGDLLKGVAKEAGLKLLNMAQCKLSGNC
Physicochemical Analysis
3050.62 Da
8.82
1.74
1.50
0.0580
0.27
0.62
0.15
-9.50
101.00
0.0333
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1235.40
-12.65
43.0
44.0
108.0
211.0
1.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0390662 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Enterococcus faecium 091299
200 μM
MIC
PMID24055160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24055160/
RECORD: Rec_0393840 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa CGMCC 1.50
400 μM
MIC
PMID24055160 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24055160/
RECORD: Rec_0409896 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0425258 VERIFIED: YES
Provenance & Taxonomy
Hylarana spinulosa [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
24-30
Bio-Activity Profile
Antimicrobial Antibacterial
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
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