Peptide Database

Peptide NameCholecystokinin-70

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC339H537N103O100S2

DescriptionStandard

        APSSAGPLKPAPRLDGSFEQRATIGALLAKYLQQARKGSTGRFSVLGNRVQSIDPTHRINDRDYMGWMDF
    

Molecular Weight7719.65 Da

Isoelectric Point (pI)10.14

Net Charge (pH 7.0)3.89

Net Charge (pH 7.4) 3.64

Charge Density (pH 7.0) 0.0555

GRAVY Index-0.57

Hydrophobic Moment 0.57

Boman Index-0.10

Instability Index41.10

Aliphatic Index 68.43

Aromaticity 0.0857

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3287.97

LogP -37.14

H-bond Donors 115.0

H-bond Acceptors 107.0

Rotatable Bonds 252.0

Heavy Atoms 544.0

Ring Count 13.0

Amide Bonds 75.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0092536 VERIFIED: YES

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyCholecystokinin

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

C-TermAmidation

Other Mods64:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Myotropic Feeding regulator

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0392218 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0424184 VERIFIED: NO

Provenance & Taxonomy

OrganismGallus gallus [Animal]

FamilyGastrin/cholecystokinin

Tax ID9031

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Other ModsTyr64 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide