Peptide Database

Peptide NameNeuropeptide Y NPYa

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic ▸ Appetite and feeding regulation ▸ Feeding regulator

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide Y family

Neurological / Signaling ▸ Sleep regulation

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Reproductive biology ▸ Reproductive modulation

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC194H294N52O57

DescriptionStandard

        YPVKPENPGEDAPAEELAKYYSALRHYINLITRQRY
    

Molecular Weight4266.72 Da

Isoelectric Point (pI)6.77

Net Charge (pH 7.0)-0.15

Net Charge (pH 7.4) -0.42

Charge Density (pH 7.0) -0.0041

GRAVY Index-0.99

Hydrophobic Moment 0.73

Boman Index-0.16

Instability Index72.23

Aliphatic Index 73.33

Aromaticity 0.1389

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1770.46

LogP -13.93

H-bond Donors 60.0

H-bond Acceptors 58.0

Rotatable Bonds 133.0

Heavy Atoms 303.0

Ring Count 10.0

Amide Bonds 38.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0067937 VERIFIED: NO

Provenance & Taxonomy

OrganismOreochromis niloticus [Animal]; Tilapia nilotica [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0081615 VERIFIED: NO

Provenance & Taxonomy

OrganismSiniperca chuatsi [Animal]; Meiacanthus atrodorsalis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0181936 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNeuropeptide Y / neuropeptide F

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0195203 VERIFIED: NO

Provenance & Taxonomy

OrganismDicentrarchus labrax [Animal]

FamilyNPY

Tax ID13489

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

NPY-family Neuropeptide Neuromodulator

RECORD: Rec_0199059 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)

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