Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length504 amino acids

Chemical FormulaC2519H3979N705O705S21

DescriptionStandard

        MMARPYCVVVALLLLAVVSGFEEGASNPGFVARITRKGLEYARRFGVAILKKELSTIKLPDFSGSFKVGWIKSVSYDFYRLKIHRFELRNSDLRLRPRQGVTASLANNYVFVSGNWKVKKAFVTLDGTFDVSVDGISISVSLNLGKDQSGRPTASVARCRSSIGHISADISGRLSWILNLFHERIENNFKNILEQKICEMVRKSTTSHLEPYLRTLPVILMIDQVAGIDYSLVGAPQVTSQILDTPFKGEFFGRNWHSPAPFDAPPIRLPEKHDHMVYFAVSEYVFNTASRAYHQAGRMNFTIQNKHVPMDSPIRLHTSSFRTIVPRLARLYPNTELELEMSPESAPFLRFTPGNVTLMPVLDIQAFALLPTSSDRKPLFQLRVQSLRRASLSLCQGTPTSTAWSSKSTRISCSWEPTLMRLNTEEGAAWLEEGTAPQLGLPPPPRGVRRLRPLCLHSSLKPPPRGHSSPGSLEHPMTPLTVGHLPHPSPPPSCALSCPLCSCP
    

Molecular Weight56093.21 Da

Isoelectric Point (pI)9.65

Net Charge (pH 7.0)19.76

Net Charge (pH 7.4) 18.54

Charge Density (pH 7.0) 0.0392

GRAVY Index-0.15

Hydrophobic Moment 0.84

Boman Index0.03

Instability Index48.59

Aliphatic Index 87.04

Aromaticity 0.0833

Extinction Coeff. Reduced 54890.00

Extinction Coeff. Oxidized 55515.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086697 VERIFIED: NO

Provenance & Taxonomy

OrganismAiluropoda melanoleuca [Animal]

FamilyBPI/LBP

Tax ID9646

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence