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MYP_114753
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Basic Information
EeCentrocin 1 Chain A (1-12)[W3A, D8A, N12K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
12 amino acids
C63H110N24O14
Standard
Sequence
GWARRTVAKVRK
Physicochemical Analysis
1427.70 Da
12.00
4.76
4.55
0.3965
-0.94
0.64
-0.50
47.58
65.00
0.0833
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
657.18
-6.13
26.0
19.0
48.0
101.0
2.0
11.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0096930 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
A2058
200 μM
IC50
PaperPubMed PMID: 31802582 PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0116517 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
200 μM
Hemolysis
PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0131439 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
A. pullulans
50 μM
MIC
PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0137442 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
50 μM
MIC
PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
RECORD: Rec_0152527 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
MRC-5
200 μM
IC50
PaperPubMed PMID: 31802582 PMID31802582 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31802582/
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