Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Enzyme modulation ▸ Enzyme inhibition ▸ Maturation inhibitor

Enzyme modulation ▸ Enzyme inhibition ▸ Protease inhibition

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC58H100N16O22S2

DescriptionStandard

        AEAMSQVANTATIM
    

Molecular Weight1437.64 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.20

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.0858

GRAVY Index0.50

Hydrophobic Moment 0.44

Boman Index0.26

Instability Index42.98

Aliphatic Index 77.14

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 625.79

LogP -8.25

H-bond Donors 21.0

H-bond Acceptors 23.0

Rotatable Bonds 47.0

Heavy Atoms 98.0

Ring Count 0.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0401848 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySynthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV

TargetHIV | CEM/LAV-1 cells

Activity110 μM

MethodIC50

Half-LifeMammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h

PaperBlocking of human immunodeficiency virus type-1 virion autolysis by autologous p2(gag) peptide. | Misumi S, Morikawa Y, Tomonaga M, Ohkuma K, Takamune N, Shoji S. | J Biochem. 2004 Mar;135(3):447-53. | DOI:10.1093/jb/mvh052 | PMID:15113844 PMID15113844 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15113844/

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