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MYP_114571
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Binding / Molecular interaction ▸ Receptor/ligand interaction
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
3 amino acids
C18H38N6O4
Standard
Sequence
KKK
Physicochemical Analysis
402.53 Da
10.30
2.76
2.55
0.9190
-3.90
0.33
-1.50
6.67
0.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
199.58
-1.25
7.0
7.0
17.0
28.0
0.0
2.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104420 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Human pancreatic carcinoma Mia PaCa-2 50% Cell death >30 microM
PMID27606830;22006001;28203232;22578748;27486068;31581500;28767074;33003569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27606830/
RECORD: Rec_0105454 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human red blood cells
10 % hemolysis at >4000 μg/mL
Hemolysis
PMID27606830;22006001;28203232;22578748;27486068;31581500;28767074;33003569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27606830/
RECORD: Rec_0106056 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Staphylococcus aureus ATCC 29213
64 μg/mL
MIC90
PMID27606830;22006001;28203232;22578748;27486068;31581500;28767074;33003569 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27606830/
RECORD: Rec_0109495 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Hexadecanoic acid (C16)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans ATCC 90028
PMID30588791 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/30588791/
RECORD: Rec_0109813 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Bacterial Permease Ligand
PaperSleigh S. H., Tame J. R. H., Dodson E. J., Wilkinson A. J.. Peptide binding in OppA, the crystal structure of the periplasmic oligopeptide binding protein in the unliganded form and in complex with lisyllysine. Biochemistry, 36, 9747-9758, 1997.
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