Peptide Database

Peptide NameRFamide

Function Ontology

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length11 amino acids

Chemical FormulaC60H102N20O15

DescriptionStandard

        DVRTPALRLRF
    

Molecular Weight1343.58 Da

Isoelectric Point (pI)11.70

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.56

Charge Density (pH 7.0) 0.1601

GRAVY Index-0.26

Hydrophobic Moment 0.22

Boman Index-0.31

Instability Index61.62

Aliphatic Index 106.36

Aromaticity 0.0909

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 588.76

LogP -4.59

H-bond Donors 22.0

H-bond Acceptors 17.0

Rotatable Bonds 42.0

Heavy Atoms 95.0

Ring Count 2.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0163293 VERIFIED: YES

Provenance & Taxonomy

OrganismCancer borealis [Animal]

FamilyFMRFamide related peptide

Tax ID39395

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

RFamide Neuropeptide Neuromodulator

RECORD: Rec_0209053 VERIFIED: NO

Provenance & Taxonomy

OrganismCancer borealis [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0257646 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Familyshort neuropeptide F

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0277041 VERIFIED: YES

Provenance & Taxonomy

OrganismCancer borealis [Animal]

FamilyRFamide

Tax ID39395

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

-

Half-LifeMammalian: 1.1 hour; Yeast: 3 min; E. coli: >10 hour