Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length486 amino acids

Chemical FormulaC2398H3694N626O715S18

DescriptionStandard

        MLQPVILLFVLGTCSAVENPGIEITVNNKGLQYGKHAGADWIQGILGNITLPFMDGRIRVGCFSSLYYTFTDTRIRKCDLPEPSVEFSPEAAGLNMSISGLSVALTGEWMASFSFLQSVGSFNMALFSVDVTSVVKLDRDNNGHLSVSSVSCEAHVENVDISLSGGASWVFQALMNRHKSQFKQNIEDGICPQVEKSIANLEHYLQVMNVSFDVDHTLAVNLSLTASPDINPSSLNVGLKGEFFSIQTHNDPPFEAQPFTVPVQGDYMFSVVLSEYTVNSALYGYYSAGLFNIFINDSMIPPDFPVHLNTSSMGPYIPQLPKALLGLQMNLQVNATSVPMVTFQPDWAKQSFHATAEAFAVQPNGTQTPLFQLRADSAFSGQSWIDAGKVKGNVSVDNFTLTLISSDVGPVNTKTLGKSTREGIEMILTRVNEALSRGLDLPRLKRAKFVNSVLKVEQGFVSFFSDAEVWPTDRGFNRPKHTHEFF
    

Molecular Weight53309.92 Da

Isoelectric Point (pI)5.30

Net Charge (pH 7.0)-12.53

Net Charge (pH 7.4) -13.47

Charge Density (pH 7.0) -0.0258

GRAVY Index0.00

Hydrophobic Moment 0.74

Boman Index0.13

Instability Index37.86

Aliphatic Index 87.00

Aromaticity 0.1008

Extinction Coeff. Reduced 47900.00

Extinction Coeff. Oxidized 48150.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0296400 VERIFIED: NO

Provenance & Taxonomy

OrganismCynoglossus semilaevis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria