Peptide Database

Peptide NameSLAY-screened peptide P1798

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC114H190N42O27S

DescriptionStandard

        LNHMHNLLHLLTRLARSFRRN
    

Molecular Weight2613.06 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)4.02

Net Charge (pH 7.4) 3.67

Charge Density (pH 7.0) 0.1915

GRAVY Index-0.49

Hydrophobic Moment 0.98

Boman Index-0.24

Instability Index102.15

Aliphatic Index 116.19

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1148.69

LogP -10.66

H-bond Donors 42.0

H-bond Acceptors 35.0

Rotatable Bonds 88.0

Heavy Atoms 184.0

Ring Count 4.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0110102 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/