Peptide Database

Peptide Namesynthetic peptide from alpha-gliadin

Function Ontology

Venom / Toxin ▸ General toxin ▸ Celiac toxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC63H101N21O16

DescriptionStandard

        HNVVHAIILHQQ
    

Molecular Weight1408.61 Da

Isoelectric Point (pI)7.02

Net Charge (pH 7.0)0.02

Net Charge (pH 7.4) -0.33

Charge Density (pH 7.0) 0.0018

GRAVY Index0.24

Hydrophobic Moment 0.20

Boman Index0.24

Instability Index61.00

Aliphatic Index 154.17

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 598.73

LogP -4.49

H-bond Donors 19.0

H-bond Acceptors 19.0

Rotatable Bonds 45.0

Heavy Atoms 100.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0097941 VERIFIED: YES

Provenance & Taxonomy

OrganismTriticum aestivum [Plant]

FamilyGliadin-derived

Tax ID4565;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Celiac toxic

Targetgliadin-reactive enterocyte / calreticulin cross-reactivity assays

PaperKrupickova S., Tuckova L., Flegelove Z., Michalak M., Walters J. R. F., Whelan A., Harries J., Vencovsky J., Tlaskalova-Hogenova H.. Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised antigliadin antibodies of patients with coeliac disease. Gut, 1999, 44, 168-173. PMID9895374 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9895374/

RECORD: Rec_0403677 VERIFIED: YES