Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length479 amino acids

Chemical FormulaC2440H3766N630O700S16

DescriptionStandard

        MMARPYYMVVALLLLAEFTRFGEGTPNPGFVARITGKGLEYAHQYGEATLKNELSTTKMHDLSGSYGIGWLGSVNYVFSGMRIHRFLLQDSQLSLHPGQGIKASLSDNYISVGGNWKVEKSFITLHGTFDLSVDGISILVSLNLGKDQSGRPTVSVIHCHNSISHVSVEISGHISWILNLFHERIENNVKPILEQKICEMVRKSAISRLEPYLRTLPVTLMIDQIAGIDYSLVGAPQVTSQGLDTHFKGEFFSRNWNTSVPFDAPPITLPQKHDHMIYFAVSEYAFNTASRVYYQAGQMKFTIQNKHIPLDFPIQLHTSSFWAIIPQLAMLYPNMELELETSPESAPFLTFTPGNVTFMPVMDIQAFVLLPNSAGRKSLFQIRASTNISITINVNSTRITGSLTTGSELKLELKDSNIGFFNVNLMESIFNYYALHTVYPSLNAKLEEGIPLPLPRDTYLNSLEFQIHENFLFLGANVD
    

Molecular Weight53638.84 Da

Isoelectric Point (pI)6.18

Net Charge (pH 7.0)-5.98

Net Charge (pH 7.4) -7.20

Charge Density (pH 7.0) -0.0125

GRAVY Index-0.00

Hydrophobic Moment 0.67

Boman Index0.14

Instability Index34.14

Aliphatic Index 95.24

Aromaticity 0.1065

Extinction Coeff. Reduced 54320.00

Extinction Coeff. Oxidized 54445.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0118379 VERIFIED: NO

Provenance & Taxonomy

OrganismCapra hircus [Animal]

FamilyBPI

Tax ID9925

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence