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MYP_114360
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Basic Information
A4K14-citropin1.1-Sp6
Anticancer
Standard
16 amino acids
C77H136N22O19
Standard
Sequence
GRFAVIKKSASVIKGL
Physicochemical Analysis
1674.04 Da
11.26
3.76
3.55
0.2348
0.56
0.53
0.12
-6.54
121.88
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
680.24
-5.70
25.0
23.0
59.0
118.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0024757 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
MCF-7
23.78 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0028245 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
A549
30.19 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0364018 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
U87
34.49 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/
RECORD: Rec_0383942 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Citropin
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
Acetylation
Amidation
Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Anticancer
C4-2B
35.84 μM
IC50
PaperWang N, Xie G, Liu C, Cong W, He S, Li Y, Fan L, Hu HG. Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides. Front Chem. 2020 Dec 10;8:616147. PMID33363118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33363118/