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MYP_114281
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Basic Information
Esculentin-1ARa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
46 amino acids
C218H376N60O62S3
Standard
Sequence
GIFSKINKKKAKTGLFNIIKTVGKEAGMDVIRAGIDTISCKIKGEC
Physicochemical Analysis
4925.88 Da
9.76
5.74
5.49
0.1248
-0.01
0.64
0.03
17.76
95.43
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2005.43
-19.13
72.0
71.0
179.0
343.0
2.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060064 VERIFIED: YES
Provenance & Taxonomy
Lithobates areolatus [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
13.0 μM
MIC
PaperM.F. Ali et al. / Biochimica et Biophysica Acta 1601 (2002) 55-63. Antimicrobial peptides and protease inhibitors in the skin secretions of the crawfish frog, Rana areolata
RECORD: Rec_0081144 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Hemolytic
human erythrocytes
180 μM
HC50
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0145309 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
RECORD: Rec_0151820 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Toxic Hemolytic
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0178706 VERIFIED: YES
Provenance & Taxonomy
Rana areolata [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
2 μM
MIC
PMID12429503 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12429503/
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