Peptide Database

Peptide NameCorticotropin

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC207H316N58O58S2

DescriptionStandard

        AYSMEHFRWGKPVGRKRRPIKVYPNGVEEESAESFPMEL
    

Molecular Weight4609.21 Da

Isoelectric Point (pI)8.43

Net Charge (pH 7.0)0.89

Net Charge (pH 7.4) 0.64

Charge Density (pH 7.0) 0.0229

GRAVY Index-0.95

Hydrophobic Moment 0.68

Boman Index-0.18

Instability Index66.44

Aliphatic Index 47.44

Aromaticity 0.1282

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1872.13

LogP -15.10

H-bond Donors 65.0

H-bond Acceptors 62.0

Rotatable Bonds 149.0

Heavy Atoms 325.0

Ring Count 11.0

Amide Bonds 39.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0106364 VERIFIED: YES

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyCorticotropin

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods13:Valine amide

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0171172 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0220039 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0281109 VERIFIED: NO

Provenance & Taxonomy

OrganismXenopus laevis [Animal]

FamilyPOMC

Tax ID8355

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsVal13 Amidation

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor