Peptide Database

Peptide NameSLAY-screened peptide P437

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC102H158N24O26S

DescriptionStandard

        PSAAVGLIPFLMARANYYLT
    

Molecular Weight2168.56 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)0.96

Net Charge (pH 7.4) 0.90

Charge Density (pH 7.0) 0.0478

GRAVY Index0.81

Hydrophobic Moment 0.27

Boman Index0.38

Instability Index35.41

Aliphatic Index 112.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 779.35

LogP -4.50

H-bond Donors 28.0

H-bond Acceptors 28.0

Rotatable Bonds 64.0

Heavy Atoms 153.0

Ring Count 5.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0069431 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/