Peptide Database

Peptide NameSLAY-screened peptide P3596

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC107H179N29O29S2

DescriptionStandard

        VNCASSIFSITFRLMIRITLN
    

Molecular Weight2399.87 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.72

Net Charge (pH 7.4) 1.50

Charge Density (pH 7.0) 0.0821

GRAVY Index1.04

Hydrophobic Moment 0.58

Boman Index0.26

Instability Index23.20

Aliphatic Index 130.00

Aromaticity 0.0952

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 956.45

LogP -8.77

H-bond Donors 36.0

H-bond Acceptors 33.0

Rotatable Bonds 79.0

Heavy Atoms 167.0

Ring Count 2.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0419971 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/