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MYP_113983
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Basic Information
Pleurain-E1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Membrane / Ion-channel modulation ▸ Calcium channel modulation ▸ Calcium channel inhibitor
Standard
26 amino acids
C132H216N38O29S
Standard
Sequence
AKAWGIPPHVIPQIVPVRIRPLCGNV
Physicochemical Analysis
2831.43 Da
10.86
2.87
2.62
0.1105
0.46
0.36
0.24
30.65
127.31
0.0385
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1027.34
-5.38
34.0
34.0
82.0
200.0
8.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0247910 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Candida albicans
25 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0298797 VERIFIED: YES
Provenance & Taxonomy
Yunnan pond [Animal]
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0304247 VERIFIED: YES
Provenance & Taxonomy
Rana pleuraden [Animal]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Yeast: Candida albicans
25 μg/mL
MIC
PMID19028675 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19028675/
RECORD: Rec_0339596 VERIFIED: YES
Provenance & Taxonomy
Nidirana pleuraden [Animal]
Pleurain
369511
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperX. Wang et al. / Peptides 28 (2007) 2069-2074. A new family of antimicrobial peptides from skin secretions of Rana pleuraden Evidence URLhttps://www.uniprot.org/uniprotkb/B5L1I5/entry
RECORD: Rec_0343349 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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