Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length460 amino acids

Chemical FormulaC2258H3613N575O660S19

DescriptionStandard

        MFLCCWLGLVALIPTTLSTNPGVKVRLTEKGIEYGRQLGMAVIQQKLGSIKIPDFSGTEKVSPIGKVQYSLSNMHIVNVGLPKSSVDLVPGTGVRMSIGDAFISLNGNWRVKYLRIIKDSGSFDLDVNGLSIATTISIKSDETGRPAVSSDSCSATVGSAKVKFHGGASWLYNLFTTFIDKALRNALQKQICPLVADAVSDLNPQLKTLNVLAKVDKYAEIEYSMVSSPTVLKSSIDLSLKGEFYNIGKHQEPPFSPAAFYLPPQNNNMLYIGMSAFTVNSAAFVYNNAGVLSLSITDDMIPKSSSIRLNTKTFGAFIPQIAKQFPGLMMKLLVKTVKTPTLTFEPNNATVQATTTVTAFAIQPNSTLSPLFVLNLEASVSARMFVSEMKLAAAVTLNKMDLTLDKSYVGDFQVRSAFLYNNTQLAKGYPLPTIGKMKLMNTQLDVLKDYILIGTDVQFS
    

Molecular Weight49984.53 Da

Isoelectric Point (pI)9.27

Net Charge (pH 7.0)10.73

Net Charge (pH 7.4) 10.20

Charge Density (pH 7.0) 0.0233

GRAVY Index0.14

Hydrophobic Moment 0.72

Boman Index0.15

Instability Index33.00

Aliphatic Index 98.33

Aromaticity 0.0848

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0353815 VERIFIED: NO

Provenance & Taxonomy

OrganismAstatotilapia calliptera [Bacterium]

FamilyBPI

Tax ID8154

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence